摘要
本文根据流体动力学平衡药物控释系统的设计原理,制备了美欧卡霉素胃内滞留漂浮型缓释片(简称MOM-HBS)。该片剂由缓释、速释两种颗粒压制而成,其胃内滞留时间长达7h以上,明显长于普通片(3～4h)。体外溶出符合一级动力学过程(Kr=0.1619h^(-1)).体内血约浓度经时曲线平缓持久,达到良好的缓释效果。体内外实验数据有显著的相关性(P<0.001),相对生物利用度较日本产干糖浆有明显提高。
A novel sustained-release tablet of miocamycin was developed based on the hydrodynamically balanced controlled drug delivery system (HBS). It was prepared to contain fast-release and sustained-release granules. The γ-scintiphotographic study after oral ingestion showed that MOM - HBS remained in human stomach for more than 7 hours, much longer than the conventional tablet (3～ 4 h). The in vitro release characteristics showed basically first- order kinetics (Kr= 0.1619 h^(-1) ). The serum concentration- time course of MOM - HBS exhibited typical sustained- release characteristics.Moreover, The percentage of drug released in vitro versus the percentage of drug released in vivo of MOM - HBS indicated excellent linearity. Its relative bioavailability was increased greatly compared with MOM dry syrup produced in Japan.
出处
《药学学报》
CAS
CSCD
北大核心
1991年第9期695-700,共6页
Acta Pharmaceutica Sinica
关键词
美欧卡霉素
缓释片剂
药代动力学
Miocamycin
Sustained release tablet
Pharmacokinetics
γ-Scintiphoto technique
