摘要
从浙江产木防己(Cocculus trilobus DC.)根中获得四种双苄基异喹啉生物碱Ⅰ～Ⅳ,通过光谱分析和化学反应证明分别为异木防己碱(isotrilobine,Ⅰ)、木防己碱(trilobine,Ⅱ).N-氧化异木防己碱(isotrilobine-Ⅳ-2-oxide,Ⅲ)及N-去甲基木防已碱(nortriiobine Ⅳ).其中Ⅲ为一新化合物。Ⅳ为首次从该植物中分得。
Four bisbenzylisoquinoline alkaloids (Ⅰ～Ⅳ)have been isolated from the roots of Cocculus trilobus DC. (Menispermaceae) growing wild in the mountainous areas of Zhejiang province. Their structures were established as isotrilobine (Ⅰ), trilobine (Ⅱ), isotrilobine- N- 2 - oxide (Ⅲ)and nortrilobine (Ⅳ)on the basis of spectral analysis (UV, IR, HNMR, MS), physico- chemical constants and properties of the derivatives. Ⅲ is a new alkaloid and Ⅳ was found from this plant for the first time.
出处
《药学学报》
CAS
CSCD
北大核心
1991年第10期755-758,共4页
Acta Pharmaceutica Sinica
关键词
木防己
化学成分
木防己碱
Cocculus trilobus DC.
Isotrilobine
Trilobine
Isotrilobine- N- 2 -oxide
Nortrilobine
Bisbenzylisoquinoline alkaloid
