摘要
本文通过凝固浴成球法,制备了颅通定/壳多糖药物缓释小球。考察了颅通定/壳多糖配比、交联剂、壳多糖分子量等因素对制剂药物含量和溶出速度的影响。结果表明,含药量56.7%的缓释小球,在模拟胃、肠液中,T_(50)分别可达40min和180min;全部溶出时间可达9h和12h。
The paper described a delivery system prepared from granulation of a chitosan solution containing rotundine in a coagulating bath and examined the effects of the ratios of rotundine: chitosan, crosslinking agents and molecular weight of chitosan on the analgesic release rate. It was shown that the rotundine (56.7%) -chitosan (Mw :5.70×10~5 degree of deacetylation: 72.4%)gelled granules in an artificial gastroenteric juice (pH 1.0 and 7.2 ) have T_(50) of 40 and 180 min respectively, and the total release time sustained over 540 min.
出处
《药学学报》
CAS
CSCD
北大核心
1991年第10期782-787,共6页
Acta Pharmaceutica Sinica
基金
国家自然科学基金
