宁国贝母中宁贝新甙的分离和结构鉴定

STRUCTURAL DETERMINATION OF NINGPEISINOSIDE ISOLATED FROM FRITILLARIA NINGGUOENSIS S.C. CHEN ET S.F.YIN

宁国贝母(Fritillaria ningguoensis S.C.Chert et S.F.Yin)为百合科贝母属新种,产于安徽皖南山区宁国县,具清热止咳、化痰散结功能,当地作贝母药用。我们曾从宁国贝母鳞茎中分得五种生物碱,分别鉴定为浙贝甲素,浙贝乙素、异贝母甲素,贝母辛及一新生物碱,命名为宁贝新(ningpeisine)。从宁国贝母总碱中又分得一种生物碱甙即宁贝甙Ⅰ和宁贝甙Ⅱ。宁贝甙Ⅰ经药理试验有明显的祛痰作用,本文报告其分离与结构鉴定。

A new steroidal alkaloidal glucoside, C_(34)H_(57)NO_7, mp 284～286℃, named ningpeisinoside, was isolated from the bulb of Fritillaria ningguoensis S.C. Chen et S F. Yin. Based on preparation of derivatives and IR, MS, ~1HNMR, ^(13)CNMR spectral studies, the structure of ningpeisinoside has been established as N- methyl- 5α- veratranine-6-oxo-3β-O-β-D-glucoside (Ⅰ).