γ-L-谷氨酰-α-萘胺在乙醇(二氧六环)/水混合介质中的电离常数研究

Study on Ionization Constant of γ-L-glutamyl-α-naphthylamine in the Mixed Solvent of Ethanol (or dioxane)/H_2O

合成了γ L 谷氨酰 α 萘胺 ,测定了该物质在乙醇 (或二氧六环 ) 水体积分数为 1 0 %、2 0%、30 %、4 0 %和 5 0 % ,离子强度 μ=0 .1 (KNO3 ) ,温度t=2 5℃条件下的电离常数pK1 和pK2 。在实验条件范围内 ,pK1 随着有机溶剂的增加而增大 ,pK2

The compound ,γ-L-glutamyl-α-naphthylamine, has been synthesized .In the mixed solvent of ethanol (or dioxane ) /H 2O in which ethanol volume ratio is 10 %?20 %?30 %?40 %?50 % respectively.The ionization constants,pK 1 and pK 2, of the compound have been determined by pH potentiometer titration at the condition of μ=0.1(KNO 3),t=25 ℃.The test result shows that pK 1 increases when the organic solvent increases , however , pK 2 agrees with the opposite rule.