3-(2-烷氧基-5-甲基苯基)-3-苯基丙胺类化合物的合成

Synthesis of 3-(2-alkyloxy-5-methylphenyl)-3-phenylpropylamines

目的设计合成 3 (2 烷氧基 5 甲基苯基 ) 3 苯基丙胺类化合物 ,从中筛选有抗尿失禁作用而无口干等不良反应的活性化合物。方法以肉桂酸和对甲酚为起始原料 ,经环合、甲基化、酰胺化、还原或再经脱甲基化得目标产物。结果共合成 10个新化合物 ,经IR ,1H

Aim To design and synthesize 3 (2 alkyloxy 5 methylphenyl) 3 phenylpropylamine derivatives,and to search for the drug for urinary incontinence with fewer side effects and improve its activities Methods The title compounds were synthesized through cyclization,methylation,amidation,reduction,or demethylation from cinnamic acid and p cresol Results Ten new compounds were obtained Their structures were confirmed by IR and 1H NMR.