乌苯美司关键中间体的合成

Synthesis of the key intermediate of bestatin

在总结文献的基础上 ,设计出一种新的乌苯美司中间体的合成方法。以苯乙醇为起始原料 ,经溴代、硝化、缩合、还原得 3 氨基 2 羟基 4 苯基丁酸。结果表明 :该合成路线原料价廉易得 ,反应条件温和 。

To modify the synthetic method of the key intermediate of bestatin,3 amino 2 hydroxy 4 phenylbutyric acid was synthesized through the steps of bromination,nitration,condensation and reduction reactions The chemical structure of the synthetic product was confirmed by IR and 1H NMR This synthetic technique is simple,moderate and easy to produce on an industrial scale.