三九胃泰四联疗法治疗消化性溃疡及根除幽门螺杆菌的多中心临床研究

Efficacies of Sanjiuweitai-based quadruple regimens for the treatment of peptic ulcer disease and eradication of Helicobacter pylori

目的 :观察含三九胃泰的四联疗法对消化性溃疡的治疗作用及根除幽门螺杆菌 (Hp)的效果。方法 :经胃镜确诊的 1 0 2例消化性溃疡患者随机分成 3组 ,试验组 (A组 ,48例 )给予三九胃泰 2 .5g +雷尼替丁 1 50mg +阿莫西林 50 0mg +甲硝唑 40 0mg ,bid ;对照组 1 (B1 组 ,31例 )给予铋剂 2 2 0mg+雷尼替丁 1 50mg+阿莫西林 50 0 mg+甲硝唑 40 0mg ,bid ;对照组 2 (B2 组 ,2 3例 )给予雷尼替丁 1 50mg +阿莫西林 50 0mg +甲硝唑 40 0mg ,bid ;以上药物除抗菌药只服用 2周外 ,其余药物服至 6周末疗程结束 ,第 7周复查胃镜和 或 1 3 C呼气试验。结果 :溃疡总愈合率A组、B1 组、B2 组分别为 90 .9% ,1 0 0 %和 86 .4% ,S2 获得率分别为 68.2 % ,73 .1 %和 45 .5 % ,Hp根除率分别为76 .1 % ,73 .3 % ,52 .6 % ,症状缓解率大致相似 ,3组均无明显不良反应发生。结论 :雷尼替丁三联疗法加用三九胃泰治疗消化性溃疡 ,可使S2 获得率增加 ,同时Hp根除率上升 ,其效果与加用铋剂效果相近 ,临床观察无明显不良反应。

Objective:To compare the efficacies of Sanjiuweitai and colloidal bismuth subcitrate based quadruple regimens for the treatment of peptic ulcer disease and eradication of Helicobacter pylori (Hp).Methods:102 patients with Hp associated peptic ulcer were randomly divided into three groups,group A( n =48) received Sanjiuweitai based quadruple regimen (Sanjiuweitai 2.5g,bid+ranitidine 150mg,bid+amoxicillin 500mg,bid+metronidazole 400mg,bid); group B 1( n =31) received colloidal bismuth subcitrate based quadruple regimen[colloidal bismuth subcitrate (Livzon) 110mg, bid+ ranitidine 150mg,bid+amoxicillin 500mg,bid+metronidazole 400mg,bid];group B 2( n =23) received ranitidine based triple regimen(ranitidine 150mg,bid+amoxicillin 500mg,bid+metronidazole 400mg,bid). Antibiotics were given for two weeks,the other drugs were given for six weeks, the efficacies were determined by gastroendoscopy or JC13,D,Z UBT.Results:The ulcer healing rate were 90.9%,100%,86.4% in group A,B 1,B 2 respectively; the stage S 2 achievement rate were 68.2%,73.1% and 45.5%; the eradication rate of Hp were 76.1%, 73.3% and 52.6%,the symptoms were remissive similarly in three groups,there were no side effects in three groups.Conclusion:Sanjiuweitai based quadruple regimen was similar to colloidal bismuth subcitrate based quadruple regimen in the ulcer healing and Hp eradication rate. [