^(67)Ga-枸橼酸显像与CT(MRI)诊断口腔颌面部肿瘤的比较

A comparative study on ^(67)Ga-Cit imaging and CT or MRI in diagnosis of maxillofacial neoplasms

目的 探讨67Ga 枸橼酸 (Cit)显像和CT(MRI)检查对口腔颌面部肿瘤的诊断价值。方法 71例口腔颌面部肿瘤患者 ,术前分别行67Ga Cit显像和CT(MRI)检查 ,术后与病理检查结果对照 ,并分别比较两组结果。结果 67Ga Cit显像 ,36例良性肿瘤患者中 2 8例阴性 ,占 77 8% ,假阳性 8例 ,占 2 2 2 % ;35例恶性肿瘤患者中 33例阳性 ,占 94 3% ,假阴性 2例 ,占 5 7%。CT(MRI)诊断 2 4例良性肿瘤患者 4例符合 ,占 16 7% ,2 0例不符合 ,占 83 3% ;2 4例恶性肿瘤患者 6例符合 ,占 2 5 0 % ,18例不符合 ,占 75 0 %。诊断肿瘤良恶性的结果两者分别比较 ,差异均有极显著性 (χ2 =2 1 6 0和19 91,P均 <0 0 1)。对判断不同大小的肿瘤 ,2种方法比较差异无显著性 (χ2 =1 2 8、0 2 6和 1 76 ,P均 >0 0 5 )。结论 67Ga Cit显像对诊断和鉴别诊断口腔颌面部良恶性肿瘤有较高的准确性 ,明显优于CT(MRI)检查。

Objective To evaluate the clinical value of 67 Ga-Citrate(Cit) imaging and CT or MRI in diagnosis of maxillofacial neoplasms. Methods Before surgery, 71 patients with maxillofacial neoplasms were studied with 67 Ga-Cit imaging and CT or MRI. All results were compared with pathological findings. Results ①In 36 patients with benign maxillofacial mass, 28 cases were with negative 67 Ga-Cit imaging (77.8%, 28/36), whereas 8 cases with positive results (22.2%, 8/36); in 35 patients with malignant tumors, 33 cases with positive 67 Ga-Cit imaging (94.3%, 33/35), whereas 2 cases with negative results (5.7%, 2/35). ②For CT or MRI, in 24 patients with benign maxillofacial mass, only 4 cases were found in concordance with pathological findings (16.7%, 4/24), but in 24 patients with malignant maxillofacial tumors, 6 cases were found in concordance with pathological findings(25.0%, 6/24). In the differentiating malignant maxillofacial tumors from benign ones, there was significant difference in accuracy between these modalities ( χ 2=21.60, 19.91, both were P <0.01). For the assessment of tumor size, there was no difference among the three modalities ( χ 2=1.28, 0.26 and 1.76, respectively, all were P >0.05). Conclusion The accuracy of 67 Ga-Cit imaging in differentiating malignant maxillofacial tumors from benign ones is significantly higher than that of CT or MRI.