桃仁不同提取物抗血栓作用的实验研究

Experimental Study on Anti-thrombus Effect of Different Extracts from Semen Persicae

目的:比较桃仁不同提取物抗血栓作用,为寻找确定其抗血栓作用有效部位提供实验依据。方法:制备桃仁不同提取物,观察其对小鼠凝血时间、ADP诱导的小鼠肺血栓状态及电刺激大鼠颈总动脉血栓形成的影响。结果:桃仁的乙酸乙酯提取物能延长小鼠的凝血时间、缓解ADP诱导的小鼠肺栓塞所致的呼吸窘迫症状,能明显延长实验性大鼠血栓形成的时间。结论:桃仁乙酸乙酯的提取物有显著的抗血栓作用。

Objective: To observe the effects of anti-thrombus of different extracts from Semen Persicae and provide experimental basis for finding and defining effective fraction of Semen Persicae. Methods:The effects of different extracts from Semen Persicae on clotting time in mice, pulmonary embolism in mice and electro-irritate thrombosis in rats were observed. Result:Ethyl acetate extract fron Semen Persicae could prolong clotting time in mice, markedly relieve respiratory difficult due to pulmonary embolism in mice induced by ADP-Na, obviously retard the generation of thrombosis induced by electrical injury of carotid artery in rats. Conclusion: Ethyl acetate extract from Semen Persicae possesses evidently anti-thrombotic effect.