摘要
目的:观察常通口服液(CTOL)对实验性肠粘连兔纤溶活性的影响。方法:仿 Thomas and Rhoads方法制作兔肠粘连模型,并以CTOL连续预防给药灌服7天后,兔耳静脉采血检测t-PA和PAI活性的变化,并肉眼观察兔肠粘连的情况。结果:CTOL各剂量组对兔术后肠粘连有明显的预防作用,并使其血中t-PA活性增高,PAI显著下降。结论:CTOL可能是通过调节机体的纤溶系统以达到防治术后肠粘连的作用。
Objective: To observe the effect of Changtong Oral Liquid ( CTOL) on the fibrinolytic activity of rabbits with experimental intestinal adhension. Methods: Intestinal adhension model of rabbits were made with reference to that described by Thomas and Rhoads and the animals were continuously orally supplemented with CTOL for seven days. Changes of tissue plasminogen activator (t-pA) and plasminogen activator inhibitor activity (PAI) as well as the intestinal adhension were investigated. Results: Different dosage of CTOL produced protective effects on the postoperative intestinal adhension accompanied by significant enhancement of t-PA activity and pronounced decreasement of PAI activity.Conclusion: CTOL maybe play protective role in postoperative intestinal adhension by modulating the activity of fibrinolytic system.
出处
《中药材》
CAS
CSCD
北大核心
2002年第6期416-417,共2页
Journal of Chinese Medicinal Materials
基金
国家重点科技攻关项目(96-901-05-245)
关键词
常通口服液
组织纤溶酶原激活剂
纤溶酶原激活剂抑制因子
肠粘连
Changtong oral liquid
Tissue plasminogen activatior
Plasminogen activator inhibitor
Intestinal adhension