复用透析器预充效果与预充技术相关因素研究

Study on the Relative Factors for Douche Effect and Douche Technique of Reused Dialyzer

目的减少复用透析器中的甲醛含量 ,降低病人费用。方法选择内循环时间 (因素A)、0 9%氯化钠溶液(NS)预充量 (因素B)、血泵流速 (因素C) 3个因素 ,各因素取 3个水平 (第 1水平为因素A 10min、因素B 10 0 0ml、因素C 2 0 0ml/min ;第 2水平为因素A 2 0min、因素B 15 0 0ml、因素C 30 0ml/min ;第 3水平为因素A 30min、因素B2 0 0 0ml、因素C 4 0 0ml/min) ,分别预充经 4 %甲醛消毒后的复用透析器 ,用低含量甲醛检测盒测试甲醛残留量。结果甲醛残留量 (μg/ml)第 1水平 3个因素分别为 1 30± 1 32、1 2 7± 1 34、1 34± 1 30 ;第 2水平分别为 0 84± 0 2 0、0 71± 0 2 0、0 79± 0 2 0 ;第 3水平分别为 0 71± 0 2 0、0 88± 0 15、0 72± 0 2 1。第 1与第 2、3水平间比较 ,均P <0 0 1,第 2与第 3水平间比较 ,P >0 0 5。结论预充中各因素均选取第 2水平即内循环时间 2 0min ,NS预充量 15 0 0ml,血泵流速 30

Objective To decrease the formalin content in the reused dialyzer and reduce the patients' cost. Methods Three factors including internal circulation time (factor A), normal saline volume of lavage (factor B) and flow rate of blood pump (factor C) were selected and each taken 3 levels: In the first level, factors A, B and C were 10 min, 1 000 ml and 200 ml/min respectively; In the second level, factors A, B and C were 20 min, 1 500 ml and 300 ml/min respectively; In the third level, factors A, B and C were 30 min, 2 000 ml and 400 ml/min respectively. The dialyzer sterilized with 4% formalin was lavaged under the above conditions and the formalin residuals were tested by low formalin content testing box. Results The formalin residuals in the 3 factors were 1 30±1 32, 1 27±1 34, and 1 34±1 30 respectively for the first level; 0 84±0 20, 0 71±0 20, 0 79±0 20 for the second level; 0 71±0 20, 0 88±0 15, 0 72±0 21 for the third level. There was significant difference between the first level and the second level or third level ( P <0 01). Conclusion The optimal compatability in lavage were internal circulation time 20 min, normal saline volume of lavage 1 500 ml and the flow rate of blood pump 300 ml/min respectively.