鼻窦癌患者血浆可溶性E-选择素的含量及意义

The clinical significance of SE-SLT in the plasma of patients with carcinoma of paranasal sinuses

目的 通过检测鼻窦癌患者血浆可溶性Ｅ－选择素[ｓｏｌｕｂｌｅ Ｅ－ｓｅｌｅｃｔｉｎ,ＳＥ－ＳＬＴ]含量来探讨其临床意义。方法 应用定量ＥＬＩＳＡ法检测１９例正常对照、２８例鼻窦癌患者及其中１９例术后患者血浆ＳＥ－ＳＬＴ含量。结果１９例正常对照组及２８例鼻窦癌组ＳＥ－ＳＬＴ含量分别为２９．８２±４．８８(μｇ/Ｌ),４４．４６±６．７８(μｇ/Ｌ);鼻窦癌Ⅰ、Ⅱ期组及Ⅲ、Ⅳ期组分别为３８．７０±５．８０(μｇ/Ｌ),５０．２０±７．２０(μｇ/Ｌ)。１９例患者术前值及术后值分别为４５．３０±６．９６(μｇ/Ｌ),３４．２８±５．１２(μｇ/Ｌ)。经检验,鼻窦癌组明显高于正常对照组(Ｐ＜０．０１),Ⅰ期和Ⅱ期组明显低于Ⅲ和Ⅳ期组(Ｐ＜０．０１),１９例术后组明显低于其相应的术前组(Ｐ＜０．０１)。结论 鼻窦癌患者血浆ＳＥ－ＳＬＴ含量与病情严重程度有关,可作为疗效观察、肿瘤转移及评估预后的参考指标。

ve To investigate the clinical significance of SE-SLT in the plasma of patients with carcinoma of paranasal sinuses. Methods SE-SLT was determined among 28 cases with carcinoma of paranasal sinuses and 19 healthy persons as controlling, by means of quantitative ELISA. Results The determined values of SE-SLT were 29. 82 ±4. 88 (μg/L)for controlling group and 44. 46±6. 78(μg/L)for the group of patients. Moreover, the patients with clinical stages I and I had a significantly lowed value of SE -SLT38. 70 ±5. 80(μg/L) than those with stages I and IV 50. 20±7-20(μg/L). Furthermore, a comparative study, made among 19 patients, showed that the SE-SLT value was significantly lowed from 45. 30±6. 96(μg/L)before the surgery to 34. 28±5.12(μg/L)after the operation. Conclusions The plasma content of SE-SLT may be related with the severity of lesion among patients with carcinoma of paranasal sinuses and can be taken as a reference index to evaluate the prognosis of this tumor.