胃粘膜组织激素与胃癌、消化性溃疡的相关性研究

Study on the relationship between the gut hormones in gastric mucosa of patients with gastic cancer and peptic ulcer

目的 研究胃泌素、胃动素、生长抑素及胰高血糖素等胃肠激素在胃癌癌组织及消化性溃疡的含量变化及它们之间的相关性。方法 内镜及活检确诊的慢性浅表性胃炎 (CSG) 2 4例 ,十二指肠球部溃疡 (DU) 2 0例 ,胃溃疡 (GU) 18例 ,胃癌 (GC) 15例 ,胃镜下取胃窦粘膜及胃癌癌组织 ,用RLA法测定胃泌素、胃动素、生长抑素及胰高血糖素的含量。结果 胃癌癌组织中 ,胃泌素、胃动素及胰高血糖素的含量分别为 168 9pg/mL± 62 5pg/mL、43 5 5pg/mL± 97 1pg/mL、12 3 4pg/mL± 41 3pg/mL ,明显高于DU(87 3pg/mL± 2 0 4pg/mL、3 72 2pg/mL± 86 9pg/mL、84 8pg/mL± 2 3 6pg/mL)、GU(92 5pg/mL± 2 6 3pg/mL、3 84 6pg/mL± 78 6pg/mL、64 9pg/mL± 18 2pg/mL)、及CSG(76 9pg/mL± 3 0 6pg/mL、2 86 7pg/mL± 64 3pg/mL、3 6 7pg/mL、14 3pg/mL)组 (P <0 0 1) ,生长抑素的含量 2 8 7pg/mL± 16 3pg/mL却显著低于DU(78 4pg/mL± 3 2 3pg/mL)、GU(86 9pg/mL± 2 8 8pg/mL)及CSG(4 6 8pg/mL± 13 4pg/mL)组 (P <0 0 1)。同时亦发现上述激素在GU及DU组的含量亦明显高于CSG组 (P <0 0 1)。结论 胃泌素、胃动素、生长抑素、胰高血糖素含量的变化可能参与了胃癌的发生、发展 ,并与溃疡的形成相关。

Aim To study the content alteration of the gastrin,motilin,somatostation and clucagon in the tissue of gastric cancer and peptic ulcer and the relationship among them.Methods 24 cases of chronic supreficial gastritis (CSG),20 duodenal ulcer (DU),18 gastric ulcer (GU) and 15 gastric cancer (GC) were studied.Antral mucosa was biopsied under the gastroscope,and the levels of gastrin (GAS),motilin (MTL),somatostation (SS) and glucagon were measured by RIA. Results The contents of Gas,MTL,Clu in the tissue of gastric cancer were 168 9pg/mL±62 5pg/mL,435 5pg/mL±97 1pg/mL,123 4pg/mL±41 3pg/mL respectively and were significantly higher than those of group DU (87 3pg/mL±20 4pg/mL,372 2pg/mL±86 9pg/mL,84 8pg/mL±23 6pg/mL),group Gu (92 5pg/mL±26 3pg/mL,384 6pg/mL±78 6pg/mL,64 9pg/mL±18 2pg/mL),and group CSG(76 9pg/mL±30 6pg/mL?286 7pg/mL±64 3pg/mL?36 7pg/mL?14 3pg/mL),but the content of somatostatin (28 7pg/mL±16 3pg/mL)was significantly lower than that of group DU(78 4pg/mL±32 3pg/mL),guoup GU(86 9pg/mL±28 8pg/mL)and group CSG(46 8pg/mL±13 4pg/mL)( P <0 01).And we also found that the hormone contents of all above in group DU and group GU were significantly higher than those of group CSG ( P <0 01).Conclusion The changes of Gas,MTL,SS and Glu in gut mucosa may play an important role in the pathogenesis of gastric cancer and peptic ulcer.