蓝光发光二极管光疗效应探讨

Blue light source in phototherapy

目的 :探讨蓝光发光二极管 (LEDs)光疗效应。方法 :在光强度仪检测下 ,调节 LEDs与普通蓝光灯的光强度使两者相同 ,然后 ,将两组光源照射胆红素标准品蛋白溶液。应用高效液相色谱仪测定溶液中胆红素光异构体的变化 ,来评价 LEDs的效应。结果 :在两组光源照射后 ,胆红素标准品蛋白溶液 ZZ的下降量和 ZE、LR的生成量无差异 (P>0 .0 5 )。结论 :LEDs能起到普通单面蓝光同样的光疗效果。

Objective: To explore the efficacy of blue light-emitting diodes (LEDs) as a novel light source for phototherapy. Methods: Equimolar bilirubin standard albumin solutions were irradiated with two light sources; LEDs and single side conventional blue light (sCBL). Light intensity was measured with a light meter. The emission intensity of LEDs was the same as sCBL. To estimate the effects of the two light sources, the change in bilirubin isomer before and during phtotherapy was determined using high performance liquid chromatography. Results : The effects of different light sources on equimolar bilirubin standard albumin solutions,the lumirubin (LR) and 4Z,15E Bilirubin Ⅸα (ZE) formation of LEDs was the same as sCBL( P >0.05). Conclusion: LEDs is equally effective as single sCBL for phototherapy in vitro.