中、晚期卵巢上皮癌242例用CP、CPT、CAP三方案化疗疗效及预后分析比较

Comparative Analysis of the Results from Treatment and Prognosis on CP,CTP and CAP Regimens for Advanced Ovarian Epithelial Cancer

目的 :探讨中、晚期卵巢上皮癌各化疗方案疗效。方法 :总结 1990年 1月～ 1999年 12月十年来 2 42例中晚期卵巢上皮癌CP、CPT及CAP方案治疗效果。结果 :≥ 6疗程 3年、 5年及 10年存活率依此为CP组6 0 6 %、 42 3%及 30 2 %,CPT组 6 4 5 %、 48 2 %及 31 4 %,CAP组 6 6 8%、 4 1%及 2 9 8%,三组间存活率无显著性差异 (P >0 0 5 )。 <6疗程 3年、 5年存活率为 5 0 1%、 30 4 %,低于≥ 6疗程的各方案组 ,但无显著性差异(P >0 0 5 )。但 10年存活率仅为 6 5 %,与≥ 6疗程各方案组相比 ,有显著性差异 (P <0 0 5 )。结论 :中、晚期卵巢上皮癌的生存时间随着化疗疗程的增加而延长 ;CP、CAP作为目前我国卵巢上皮癌的第一线化疗方案仍具有重要意义。

Objective:To study the effect of treatment from various chrmotherapy regimens for advanced ovarian epithelial cancer.Methods:From 1990.1～1999.12,the curative effects from CP,CTP and CAP regimens for 242 cases advanced ovarian epithelial cancer were summarized.Results:To≥6 courses,the survival rates of 3yr,5yr and 10yr from CP,CTP and CAP regimens have no significant difference(P>0.05),but the significant drfference of the 10yr survival rate was found between≥6 courses and <6 courses(P<0.05).Conclusion:The survival time would be prolonged along with the increase of the course of chemotherapy to advanced ovarian epithelial cancer.Nowdays,as the first-line chemotherapy regimen,CP and CAP still worked very well in China.