抗白细胞药物治疗急性脑出血的随机对照研究

Study of Randomized Controlled Trial in Treating Acute Cerebral Hemorrhage with Anti-leukocyte Drugs

目的 :评价环磷酰胺、秋水仙碱治疗急性脑出血的效果。方法 :5 8例急性脑出血患者随机分为试验组和对照组 (各 2 9例 )。对照组给予一般治疗 ,试验组在此基础上再加用环磷酰胺 0 1～ 0 2g静滴和秋水仙碱1mg口服 ,每天 1次 ,共 10天。采用改良爱丁堡—斯堪的那维亚中风量表 (modifiedEdinbergh -Scandinaviastrokescale,MESSS)分别于入院时 ,病后 7天、 14天、 1月、 2月、 3月进行神经功能缺损评分 ,用BarthelIndex (BI)分别于发病后 1月、 2月、 3月进行日常生活能力评分。结果 :病后 1月、 2月和 3月试验组神经功能缺损评分显著低于对照组 (P <0 0 5 ) ;2月、 3月试验组BI评分高于对照组 (P <0 0 5 )。结论 :环磷酰胺、秋水仙碱治疗急性脑出血患者 ,具有减轻患者神经功能缺损 ,提高患者独立生活能力的作用。

Objective:To evluate the effects of cycolphosphamide and colchicine on patients with acute cerebral hemorrhage.Method:Fifty-eight patients with acute cerebral hemorrhage were diveded into treatment group and control gruop(28 patients in each).The control group was given general therapy;the treatment group was given the cyclophosphamide 0.1～0.2g and colchicine 1mg per day for 10 days besides the general therapy.The neurological functional defects at admission,after onset day 14,month 1,2 and 3 were evaluated with modified Edinbergh-Scandinavia Stroke scale(MESSS)and the activity of daily living(ADL)after onset at month 1,2 and 3 was evaluated with Barthel Index(BI).Results:Compared with those of the control group,the scores of MESSS of the treatment group after onset at month 1,2 and 3 were lower than those of the control group(P<0.05).The csores of BI of the treatment group after onset at month1,2 and 3 were higher than those of the control group(P<0.05).Conclusion:Cyclophosphamide and colchicine would reduce the neurological functional defects of patients with acute cerebral hemorrhage and improve the ability of independence of those patients.