1Obrien C. New tumor suppressor found in pancreatic cancer. Science,1996,271(5 247) :294
2White R L. Tumor suppressing pathways. Cell, 1998,92(5) :591
3Zhang Y, Musci T, Derynck R. The rumor suppressor Smad4/DPC4 as a central mediator of Smad function.Curr Biol, 1997,7(4) :270
4Mehra A, Wrana J L. TGF-beta and the Smad signal transduction pathway. Biochem Cell Biol, 2002,80 (5):605
5Fukuchi M, Masuda N, Miyazaki T, et al. Decreased Smad4 expression in the transforming growth factor-beta signaling pathway during progression of esophageal squamous cell carcinoma. Cancer, 2002,95 (4) : 737
6Markowitz S. Inactivation of the TypeⅡ TGF-β reception colon cancer cells with microsatellite instability. Science1995,268(5 215):1 336
7Wang J, Sun L, Myeraff L, et al. Demonstration that mutation of the type Ⅱ TGF-β receptor error positive colon carcinoma cells. J Biol Chem,1995,270(37):22 044
8Hunt KK, Fleming JB, Abramion A, et al. Overexpression of the tumor supression gene Smad4/DPC4 induces P21wafl expression and growth inhibition in human carcinoma cell. Cancer Research,1998,58(24):5 656
9Boulaire J, Fotedar A, Fotedar R. The function of the cdk-cyclin kinase inhibitor p21. Pathol Biol,2000,48(3):190
10Kaya H, Kotiloglu E, Inanli S, Ekicioglu G, Bozkurt SU,Tutkun A, Kullu S. Prevalence of human papilloma virus(HPV)DNA in larynx and lung carcinomas. Pathologica 2001;93:531-534
