胎膜早破患者细菌性阴道病阴道唾液酸酶活性的检测

Vaginal Sialidase Activity Assay in Bacterial Vaginosis Patients with Preterm Premature Rupture of Membranes

目的 探讨细菌性阴道病 (bacterial vaginosis,BV)与胎膜早破及早产的关系。 方法 我们采用阴道分泌物唾液酸酶比色检测法 ,检测了 10 4例胎膜早破孕妇和 80例足月正常妊娠妇女阴道分泌物中的细菌唾液酸酶水平。 结果 10 4例胎膜早破孕妇中 38例 (36 .5 4 % ) BV呈阳性 ;80例足月正常妊娠孕妇中 9例 (11.2 5 % ) BV呈阳性 (P<0 .0 1)。胎膜早破孕妇中合并早产 4 6例 ,其中2 6例 (5 6 .5 2 % ) BV呈阳性 ,平均出生体重为 2 180 g;足月妊娠胎膜早破 5 8例 ,其中 12例 (2 0 .6 9% )BV呈阳性 (P<0 .0 1)。 结论 细菌性阴道病可使胎膜早破、早产和低体重出生儿的危险性增加。

Objective To study the relationship between the bacterial vaginosis (BV) and the preterm premature rupture of membranes and premature labor. Methods Qualitative and colorimetric test was used to detect the presence of bacterial sialidase level in 104 pregnant women with preterm premature rupture of membranes and 80 women with normal full term pregnancy. Results 38 cases were positive of BV in patients with premature rupture of membranes (36.54%) and nine cases were positive in normal full term pregnancy (11.25%) ( P <0.01). 26 cases were positive of BV in 46 patients with preterm premature rupture of membranes ( 56.52% ),the average of birth weight of the preterm delivery infant was 2 185 g ;12 cases were positive of BV in 58 patients with term premature rupture of membranes (20.69%)( P <0.01). Conclusion The elevated vaginal bacterial sialiase level and bacterial vaginosis are associated with increased rates of premature rupture of membranes, preterm delivery and low birth weight infants.