全氟辛烷对角膜影响的实验研究

Experimental study on effect of perfluoroetane on corneas

目的 观察全氟辛烷残留前房时对角膜的影响 ,探讨取出残留前房全氟辛烷的适宜时间。方法 向实验组兔眼前房中注入全氟辛烷 ,观察不同时间内角膜在裂隙灯显微镜、光镜、扫描电镜下和台盼蓝、茜素红染色后的变化。结果 实验组的角膜 2周时只在扫描电镜下出现变化 ,4周时的检查结果显示角膜明显改变。结论 全氟辛烷长时间残留眼内可引起角膜内皮细胞的损伤 ,应尽早取出前房内的全氟辛烷。

Objective To observe the effect of perfluoroetane in the anterior chamber on cornea and determine proper time when residual perfluoroetane should be take out of from the anterior chamber. Methods After perfluoroetane was injected into rabbit anterior chamber, corneas were observed at 2, 4 weeks postoperately. Results Experimental corneas are different from normal corneas only under scanning electromicroscopy after 2 weeks postoperatively. After 4 weeks, more apparent change was found. Conclusion Perfluoroetane can injure endothelium in anterior chamber for long time . So perfluoroetane should be taked out of as early as possible.