摘要
目的 检测急性弥漫性腹膜炎患者血清中白细胞介素 1 0 (IL 1 0 ) ,并探讨IL 1 0在急性弥漫性腹膜炎发病中意义。方法 41例急性弥漫性腹膜炎患者和 2 0例健康人血清IL 1 0的测定采用双抗体夹心ELISA检测法。结果 急性弥漫性腹膜炎患者入院时、术后第 1、3、6天血清IL 1 0浓度分别为 42 3 7± 3 1 6、3 51 2± 2 7 3、2 2 4 5± 2 3 6、1 0 3 6±2 1 7pg/ml,健康人血清IL 1 0浓度为 92 5± 2 1 6pg/ml。与健康人比较 ,急性弥漫性腹膜炎患者入院时血清IL 1 0明显升高 (P <0 0 1 ) ,术后第 1、3、6天逐渐下降至正常。结论 IL 1 0增加是机体的一种防御反应。
Objective To detect serum interleukin?10(IL?10) in the patients with acute diffuse peritonitis and to analyse the significance of IL 10 in the course of acute diffuse peritonitis. Methods Serum IL 10 of 41 cases of acute diffuse peritonitis and 20 cases from healthy blood donors were detected by double antibody(sandwich) ELISA.Results Serum IL 10 concentrations in patiaots with acute diffuse peritowitis on immediately admitel, and l ?3 ?6 d after operation were 423 7±31 6,351 2±27 3,224 5±23 6,103 6±21 7,respectively, the average level of the health is 92 5±21 6 pg/ml?Compared with the health,serum IL 10 concentrations of cases with acute diffuse peritonitis were signifycantly higher, and decreased gradually on l?3?6 d after operation to normal.Conclusion IL?10 participates in path ogenesy of acute diffuse peritonitis. The increase of serum IL?10 concentration is a deffensive reaction of the body.
出处
《中国实验诊断学》
2002年第3期171-172,共2页
Chinese Journal of Laboratory Diagnosis
