摘要
慢性非感染性疾病已经成为威胁中国人健康的主要原因。肥胖是其中起重要作用,需积极治疗的因素之一。对肥胖病理意义的认识经历了由宏观至微观,由全身至局部、细胞乃至分子水平的深入过程。肥胖病人脂肪的积聚,并由脂肪细胞流向非脂肪细胞,产生非脂肪细胞脂质异位沉着,同时使得脂肪细胞内分泌功能发生紊乱是造成脂肪中毒作用及其严重后果的病理生理机制。温故而知新,正确评价肥胖治疗的方法,提供适宜的积极治疗选择,展望未来的治疗,强化控制体重达标将是一个十分广阔的研究领域。
Obesity has now replaced undernutrition and infectious diseases as the most significant contributor to ill health. Major advances have now been made in identifying the components of the homeostatic system that regulates body weight, including several genes responsible for animal and human obesity. A key element of the pathophysiological machanism of obesity is the 'lipotoxicity' and the disturbance in the fat cell hormone. We will provide further insight into the present management of obesity, and possibilities for new treatment.
出处
《药学服务与研究》
CAS
CSCD
2002年第2期73-78,共6页
Pharmaceutical Care and Research
关键词
现状
展望
肥胖症
治疗
obesity
lipotoxicity
treatment
