不同剂量辛伐他汀的调脂疗效比较

Comparison of therapeutic effect of different dosages of simvastatin on patients with hyperlipoidemia

目的:观察不同剂量的辛伐他汀对高脂血症病人的疗效与安全性。方法:80例病人随机分为A、B两组,A组辛伐他汀剂量为20mg/d,B组为5mg/d,门诊治疗6周。试验前后分别测定血脂、肝功能及磷酸肌酸激酶。结果:A组的达标率为70％,而B组的达标率仅为23％。两组均未发现明显的肝功能损害及肌病。其余不良反应发生率基本相似。结论:20mg/d的辛伐他汀调整血脂作用比5mg/d的更好,而且使用安全。

Objective: To evaluate lipid-lowering effect of a large dose(20 mg/d) of simvastatin and compare it with that of small dose (5 mg/d) of simvastatin. Methods: Eighty patients were randomized to two groups. Simvastatin dosage was 20 mg/d for group A and 5 mg/d for group B. The follow-up period was 6 weeks. Blood lipids were determined before and after the study. Liver function and creatine phosphate kinase concentration were also determined. Results: Group A had a more marked lipid-lowering effect than group B. The target-reaching rate in group A was 70%, which was much higher than that in group B(23%). There was no severe liver dysfunction or myopathy in both groups. The incidence of other drug adverse effect was quite low, and there was no significant difference between the 2 groups. Conclusion: Simvastatin 20 mg/d is more effective than 5 mg/d simvastatin, and can be used safely in clinical practice.