箭叶淫羊藿叶水提取液抗心律失常作用的研究

The Anti-arrhythmia Effect of Epimedium Breuicornum Maxin(EBM)

目的 :了解箭叶淫羊藿叶 (EpimediumBreuicornumMaxinEBM )水提取液的抗心律失常作用。方法 :常规抗心律失常的方法。结果 :箭叶淫羊藿叶水提取液对氯仿诱发的小鼠室颤 ,氯化钙诱发的大鼠室颤均有明显的预防作用 ,对乌头碱诱发的大鼠心律失常有明显的治疗效果。但不能对抗肾上腺素诱发的家兔心律失常。箭叶淫羊藿叶水提取液可降低蟾蜍离体坐骨神经动作电位。结论 :提示箭叶淫羊藿叶水提取液抗心律失常作用可能与其抑制Na+,Ca2 +内流有关。进一步提示箭叶淫羊藿叶水提取液抗心律失常作用可能与其抑制Na + ,内流有关。而与阻断 β—肾上腺素受体无关。

Objective:To study the anti arrhythmia effect of Epimedium Breuicornum Maxin(EBM).Methods:The conventional anti arrhythmic methods were used.Results:It had been found that EBM was markedly effective in preventing ventricular fibrillation induced by chloroform in mice and induced by calcium chloride.EBM can markedly inhibit the arrhythmia induced by aconitine in rats.But EBM cannot antagonize the arrhythmia induced by adrenaline in rabbits.And EBM can obviously inhibit the action potential amplitude of isolated sciatic nerves in toads.Conclusion:EBM has obviously protective effect on drugs induced arrhythmia,which may be related to its inhibition of Na + or Ca 2+ influx.