急性河豚中毒患者P_(300)的研究

Study on P_(300) in patients with acute puffer poisoning

目的 研究急性河豚中毒患者的P3 0 0 的改变。方法 应用纽科公司的Medicid 0 3E脑诱发电位仪测定 2 1例急性河豚中毒患者的视觉 (图像 )、听觉刺激诱发P3 0 0 波之潜伏期和波幅 ,与 30例正常对照组作比较 ,并比较不同病情患者的P3 0 0 波改变。结果 病例组视觉 (图像 )、听觉刺激P3 0 0 波的潜伏期较正常对照组明显延长 (P <0 .0 0 1) ,波幅明显降低 (P <0 .0 0 1)。P3 0 0 波之潜伏期和波幅与患者病情严重程度相关 ,随着中毒症状的改善 ,P3 0 0 波的潜伏期逐渐缩短 ,波幅也逐渐增高。结论 P3 0 0 波的变化可作为判断急性河豚中毒患者脑认知功能障碍程度和恢复情况的一项客观指标。患者P3 0 0

Objective To study the change of P 300 in patients with acute puffer poisoning.Methods With medicid-03E brain evoked potential instrument of Neuronic Company. the latency and the amplitude of P 300 evoked by visual (image) and audio stimulation were measured in 21 patients with acute puffer poisoning, these patients were compared with 30 normal subjects and compared with the P 300 during different condition of poisoning.Results The latency of P 300 evoked by visual (image) and audio stimulation in patient group was significantly prolonged as compared with the control group (P<0.001),and the amplitude was significantly decreased (P<0.001).Both the latency and the amplitude of P 300 were related to the severity of the disease, with the improvement of the symptomatic poisoning, the latency of P 300 was shortened and the amplitude increased gradually.Conclusion The change of P 300 may be taken as an objective index of judging the changes and recovery condition of the brain cognitive function in patients with acute puffer poisoning. The dynamic observation of P 300 in patients was more significant.