盐酸维拉帕米自乳化缓释片的研制及释药行为的探讨

Development of Verapamil Hydrochloride Self-Emulsifying Sustained-Release Tablets and Exploration of Released Character

目的 探索固体自乳化释药系统 ,研制自乳化缓释片 ,考察体外释药行为。方法 以盐酸维拉帕米 (VerapamilHydrochloride ,VH)为模型药物 ,以吐温 80 (Tween80 ) ,豆磷脂 (sbpc)为乳化剂 ,以羟丙甲纤维素(HPMC) ,卡波普 (carbopol)为骨架材料 ,制备自乳化缓释片。结果 以含吐温 80和豆磷脂 10 % ,羟丙甲纤维素和卡波普 30 %的处方乳化效果好 ,体外释药符合要求。结论 通过调节乳化剂和骨架材料的比例 。

AIM Self emulsifying drug delivery systems were studied. Verapamil Hydrochloride self emulsifying sustained release tablets were developed and evaluated \%in vitro\% release characteristics. METHODS The Verapamil Hydrochloride formulations were screened according to the designed \%in vitro\% release rate by the use of Tween80, Sbpc as emulsifier and HPMC, and carbopol as the gel matrix. RESULTS The self emulsifying sustained release tablets prepared containing 10% emulsifier and 30% gel matrix were preferable. CONCLUSION Adjusting the ingredients of formulation may obtain the desirable self emulsifying sustained release tablets.