HLA-DR抗原在斑秃皮损中的表达

Study on the expression of HLA-DR antigens in alopecia areata lesions

目的 : 探讨斑秃的发病机理。方法 : 应用免疫组化的方法 (SP法 )观察了HLA -DR抗原在 15例斑秃皮损中及 8例正常头皮组织中的表达情况。结果 : HLA -DR抗原在斑秃皮损毛囊角质形成细胞中明显表达 ,占 6 0 %(9 15 ) (P <0 .0 5 ) ;HLA -DR抗原在正常头皮中未见表达。结论 : HLA-DR抗原参与了斑秃发病 ,免疫功能紊乱可能是斑秃的发病因素。

Objectives:Objective: To investigate the pathogenesis of alopecia areata (AA).Method:Immunohistochemical technology (SP method) was used to detect the HLA-DR antigens in scalp specimens from15 cases of AA and 8 normal controls. Results: HLA-DR antigens were obviously expressed on follicular keratinocytes in AA lesions (9/15), but not in normal scalp skin (P<0.05) Conclusion: HLA-DR antigens play a role in AA, and immune dysfunction may be a possible mechanism that results in the development of AA.