儿童血脂及脂蛋白水平与冠心病家族史关系分析

Relation of Levels of Lipids and Lipoproteins in Children to Family History of Coronary Heart Disease.

【目的】 探讨冠心病家族史与儿童血脂水平的关系。 【方法】 采用病例对照研究方法对 173名年龄在 7～ 10岁 ,且个体体重是身高标准体重的 90 %～ 110 %的健康儿童进行血脂水平分析。病例组由 5 0名冠心病家族史阳性儿童组成 ,对照组由 12 3名冠心病家族史阴性儿童组成。 【结果】 在对年龄、性别修正后 ,冠心病家族史阳性儿童其血清高密度脂蛋白胆固醇及载脂蛋白A水平明显低于对照组 (P <0 .0 1) ,分别为 (1.3 7± 0 .0 4)mmol/L和(13 2 0 .85± 2 0 .18)mg/L ;而对照组为 (1.5 2± 0 .0 3 )mmol/L和 (13 96.92± 12 .85 )mg/L。 【结论】 冠心病家族史对即使无肥胖因素儿童的血脂水平也有一定的不利影响。

To investigate the relationship between family history of coronary heart disease (CHD) and the levels of lipids and lipoproteins. A case control study was performed in 173 children whose weight for height was 90%～110% of the ideal weight. The case group consisted of 50 children whose first or second relatives had suffered from CHD. The control group was composed of 123 subjects without any family history of CHD. In both groups, serum lipid variables were measured. After adjusting of age and sex, the levels of high density lipoprotein cholesterol and apolipoprotein A were significantly lower in the children with family history of CHD than in control subjects [(1.37±0.04)mmol/L vs.(1 320.85±20.18)mg/L;(1.52±0.03)mmol/L vs.(1 396.92±12.85)mg/L, P <0.01,respectively]. [Conclusion] The CHD family history influences on the levels of lipids even in the non obesity children.