异丙酚伍用不同剂量芬太尼麻醉用于胃镜检查的临床研究

Propofol with different dosage of fentanyl for gastroscopy anesthesia

目的 研究异丙酚联合应用不同剂量的芬太尼在胃镜检查术中的麻醉作用。方法 68例自愿接受麻醉下胃镜检查患者随机分为三组。A组为对照组(n=24),静注异丙酚2mg/kg;B组(n=24)静注异丙酚2mg/kg及1μg/kg芬太尼;C组(n=20)静注异丙酚2mg/kg及2μg/kg芬太尼。异丙酚均于45～60秒缓慢注入。观察三组患者诱导及苏醒时间、异丙酚用量及呼吸抑制情况。结果 麻醉诱导时间B、C两组少于A组(P<0.01),苏醒时间B组少于A组(P<0.05)。异丙酚用量B、C两组均少于A组(P<0.01)。呼吸抑制发生率A组41.7％、B组45.8％、C组85.0％,A、B两纽的发生率接近,无明显差异,但两纽均与C组相差显著(P<0.05)。而呼吸抑制的平均时间B组为最短。结论 异丙酚联合应用芬太尼用于胃镜检查术可加强镇痛,减少异丙酚用量。异丙酚联合应用1μg/kg芬太尼,是一种较为安全有效的配伍方法。

Objective To explore the effect of propofol anesthesia with different dosage of fentanyl in gastroscopy Methods Sixty-eight gastroscopy patients were randomly into three groups. Group A (control group, n=24)was administrated propofol 2mg/kg only; group B(n=24) was administrated propofol 2mg/kg with 1 μg/kg fentanyl; group C (n=20) was 2mg/kg propofol with 2μg/kg fentanyl. Induction time, recovery time, the dosages of propofol and respiration depression were recorded. Results Propofol dosage in group B and C was less than that in group A (P<0.01). Respiration depression occurrence of group A, B and C was 41.7%, 45.8% and 85% respectively. Conclusion Propofol with fentanyl for gastroscopy anesthesia may enhance analgesia and reduce the propofol dosage. Propofol with 1μg/kg fentanyl is a safe and effective protocol for gastroscopy anesthesia.