多发性骨髓瘤32例临床分析

Clinical Analysis on Multiple Myeloma of 32 Cases

目的 :探讨多发性骨髓瘤的临床特征。方法 :采用回顾性分析的方法。结果 :该病发病缓急程度相差大 ,无症状期 2周至 4年不等 ,绝大多数病人有发烧、骨痛、乏力等症状和肝脾肿大、淋巴结肿大等体征 ,患者均有Ig异常 ,其中IgG异常者最常见。结论 :骨髓瘤预后差 ,VAD治疗方案疗效较好 。

Objective: To discuss the clinical features of multiple myeloma. Methods: Retrospective analysis was utilized. Results: 1.Moyeloma might be with insidious onset or acute onset and with wide range of asymptomatic period from 2 weeks to 4 years. 2.Most patients showed the symptoms of anemia, bone pain and infection and revealed the signs related to the enlargement of liver, spleen and lymphonode. 3.The hallmark of myeloma is the finding of a monoclonal paraprotein on serum protein electrophoresis, mainly IgG paraprotein. Conclusion:1.Myeloma is a disease of older adults (median age at presentation, 51 years). 2.Anemia is nearly universal, paraprotein is a hallmark. 3. The goal of treatment of myeloma is usually palliative. Treating patients with VAD regimen shows better outcome in both remission duration and longer survival.Additional IFN administration may also be beneficial.