卡介苗素对单纯性肾病综合征患儿血、尿sIL-2R水平的影响

Effect of vaccine injection on serum and urinary sIL-2R in children with simple nephrotic syndrome

目的 观察卡介苗素注射液对单纯性肾病综合征 (SNS)患儿血、尿sIL 2R的影响。 方法 SNS初治患儿 38例 ,随机分为卡介苗素组 2 2例和强的松组 16例 ,另设正常组 2 5例 ,用ELISA法检测两组患儿用药前及用药 3个月后血清、尿可溶性白介素 2受体 (sIL 2R)。 结果 卡介苗素组的血清sIL 2R下降显著高于强的松组 (2 4 8± 5 4U/ml比 5 11± 72U/ml,q =8.4 72 ,P <0 .0 1) ,与正常组比差异无显著性 (2 4 8± 5 4U /ml比 2 4 5± 6 1U/ml,q =0 .112 ,P >0 .0 5 ) ,而强的松组仍显著高于正常组 (5 11± 72U/ml比 2 4 5± 6 1U/ml,q =9.0 74 ,P <0 .0 1)。尿sIL 2R与血清sIL 2R一样也发生上述显著变化。 结论 卡介苗素具有显著降低SNS患儿血、尿sIL 2R水平的作用 ,提高了患儿的细胞免疫功能。

Objective To observe the effect of vaccine injection on serum and urinary soluble interleukin 2 receptor (sIL 2R) in children with simple nephrotic syndrome (SNS). Methods Thirty eight children with SNS were randomly divided into 2 groups: vaccine treatment group (n=22) and prednison group (n=16).In addition,25 children were selected as a normal control group. The treatment of prednison used for 6 months was administered in 2 groups , while 0.5mg (1ml) vaccine injection by intramuscular injected on alternate days was added to vaccine group for 3 to 6 months. The levels of serum and urinary sIL 2R were determined by ELISA method before and after vaccine being used for 3 months in vaccine group, prednison group and normal control group, respectively. Results The level of sIL 2R in serum and urine of normal group was 245±61 U/ml and 244±49 U/ml, respectively. After treatment,the level of serum sIL 2R was significantly decreased more in vaccine group than that in prednison group(248±54 U/ml vs 511±72 U/ml,q=8.472,P<0.01) and closed to the level in normal group (q=0.112,P>0.05), but the level of serum sIL 2R in prednison group was still higher than that in normal group significantly(q=9.074,P<0.01). The changes of urinary sIL 2R were same with serum sIL 2R. Conclusion The vaccine has the effect of which obviously declined the levels of serum and urinary sIL 2R in children with SNS, and thus, improved their cell immune function.