摘要
目的 :探讨利培酮治疗精神分裂症时对其心电图的影响 ,并与氯丙嗪、氯氮平对照研究 ,以观察利培酮的安全性。方法 :将病人随机分为利培酮、氯丙嗪、氯氮平 3组 ,分别于治疗前及治疗高量期 (6周± )检查心电图 ,观察心电图变化。结果 :利培酮所致心电图异常发生率最小 ,3组药物间的心电图异常存在明显的差异 ,(χ2 =5 9.30 ,P <0 .0 1)。结论 :利培酮所致心电图改变明显低于氯丙嗪 ,更低于氯氮平。虽然 3组药物对心电图均有影响 ,表明利培酮相对安全 ,对既往有心脏病史、年老体弱者 ,建议优先选用利培酮。
Objective: To study the affect on Risperidone to electrocardiogram of the patients with schizophrenia, and compare with Chlorpromazine and Clozapine, in order to observe the safety of Risperidone. Method: Dividing the patients into 3 groups for Risperidone, Chlorpromazine and Clozapine at random. Checking the electrocardiogram both before treating and in 4~8 weeks treating period, and observing the variations of electrocardiogram. Results: The occurrence of abnormal electrocardiogram caused by Risperidone is minimum, the abnormal electrocardiogram among in the 3 groups of medicines exist obvious differences (χ 2=59.30, P<0.01). Conclusion: The variations of electrocardiogram caused by Risperidone is lower than Chlorpromazine obviously and even lower than Clozapine. Although in the 3 groups of medicines are effective to electrocardiogram, Risperidone is more secure. The general and asthenic persons and the patients with heart disease are suggested to select it first.
出处
《天津药学》
2002年第3期54-55,共2页
Tianjin Pharmacy