利培酮、氯丙嗪、氯氮平对分裂症病人心电图影响的对照分析

A comparative study of the effects of Risperidone, Chlorpromazine and Clozapine to patients with Schizophrenia by the electrocardiograms

目的 :探讨利培酮治疗精神分裂症时对其心电图的影响 ,并与氯丙嗪、氯氮平对照研究 ,以观察利培酮的安全性。方法 :将病人随机分为利培酮、氯丙嗪、氯氮平 3组 ,分别于治疗前及治疗高量期 (6周± )检查心电图 ,观察心电图变化。结果 :利培酮所致心电图异常发生率最小 ,3组药物间的心电图异常存在明显的差异 ,(χ2 =5 9.30 ,P <0 .0 1)。结论 :利培酮所致心电图改变明显低于氯丙嗪 ,更低于氯氮平。虽然 3组药物对心电图均有影响 ,表明利培酮相对安全 ,对既往有心脏病史、年老体弱者 ,建议优先选用利培酮。

Objective: To study the affect on Risperidone to electrocardiogram of the patients with schizophrenia, and compare with Chlorpromazine and Clozapine, in order to observe the safety of Risperidone. Method: Dividing the patients into 3 groups for Risperidone, Chlorpromazine and Clozapine at random. Checking the electrocardiogram both before treating and in 4～8 weeks treating period, and observing the variations of electrocardiogram. Results: The occurrence of abnormal electrocardiogram caused by Risperidone is minimum, the abnormal electrocardiogram among in the 3 groups of medicines exist obvious differences (χ 2=59.30, P<0.01). Conclusion: The variations of electrocardiogram caused by Risperidone is lower than Chlorpromazine obviously and even lower than Clozapine. Although in the 3 groups of medicines are effective to electrocardiogram, Risperidone is more secure. The general and asthenic persons and the patients with heart disease are suggested to select it first.