乙型肝炎患者血清氧自由基变化与病变程度及病毒含量的关系

Relationship between Oxygen Free Radical and Disease Status, HBV DNA Load in Patients with Hepatitis B

目的:研究乙型肝炎患者血清氧自由基与病变程度及病毒含量的关系。方法:103例乙型肝炎患者分为单纯携带组（XD）、急性肝炎组（AH）、慢性活动性肝炎组（CAH）及肝硬化组（LC）,另设对照组20人。分别测定其血清超氧化物歧化酶（SOD）及丙二醛（MDA）;40例CAH患者行HBV-DNA定量分析后,其中19例予常规保肝、退黄治疗,另21例在此基础上加用抗病毒治疗,疗程6个月后复测血清HBV-DNA、SOD及MDA水平。对各组间SOD、MDA水平及治疗前后HBV-DNA水平、SOD及MDA进行统计分析。结果:各组乙型肝炎患者与正常对照组比较SOD及MDA变化显著（P<0.05）。CAH患者抗病毒治疗后HBV-DNA含量下降,伴随SOD上升及MDA下降。结论:乙型肝炎患者血清氧自由基代谢异常,其水平与病变程度及病毒含量明显相关。

Objective:To investigate the relationship between oxygen free radical(OFR) and disease status,HBV DNAloads in patients with hepatitis B, Methods: According to their disease status,103 patients with hepatitis B were divided into HBV carrier(XD)( n =20) .acute hepatitis( AH) ( n =20) .chronic acute hepatitis(CAH)( n = 40)and liver cirrhosis(LC) (n = 23)groups. Another 20 healthy people were set as control group, In CAH group, 21 patients were given an anti-virus treatment for 6 months,and others were given an ordinary treatment. Before and after treatment,the levels of HBV DNA.superoxide dismutase(SOD) and MDA were measured in all of the patients and healthy people. Results: Compared with the control group, the levels of SOD and MDA in hepatitis B groups changed more significantly than in the control group(P <0.05) . In CAH group,HBV DNA loads reduced apparently after the anti-virus treatment, along with SOD being up and MDA being down. Conclusion: The metabolism of OFR is obviously abnormal in the patients with hepatitis B. Its level is significantly correlative with disease status and HBV DNA loads.