主动脉夹层的病理形态学研究

Study of Pathomorphological Features in Aortic Dissection

目的:通过对主动脉夹层病理形态学研究探讨其发病机理。方法:对32例主动脉夹层标本和10例正常主动脉壁标本进行病理学检测。结果:（1）弹力纤维断裂、囊性中层退行性变、中层坏死等病理改变并非主动脉夹层所特有,正常主动脉壁亦可出现上述组织学改变。（2）病变的严重程度随年龄的增加而加重（P<0.05）,且与主动脉夹层的发生并无必然联系。结论:（1）主动脉夹层并没有特征性组织病理改变作为其发病基础。（2）主动脉夹层的发病机制可能是局部性损伤-修复机制。

Objective: To study the pathomorphological features in aortic dissection and their pathogenesis. Methods: The samples of 32 cases of aortic dissection and 10 cases of normal aortic wall were examined pathologically. Results: (1) Some histopathological features, such as elastin fragmentation, cystic medial retrograde affection, medionecrosis and fibrosis were not specific for aortic dissection. Each of these histopathological features could occur in normal aorta. (2) These histopatho logical features in aortic dissection were not causative for this disease process and showed a striking correlation with age(P < 0 .05) .Conclusion; (1)No specific histopathological defect can be hold responsible for the pathogenesis of aortic dissection. (2) The pathogenesis of aortic dissection is probably the process of local injury and repair.