国产昂丹司琼加地塞米松防治顺铂化疗引起的呕吐

Ondansetron plus dexamthasone in anti-emesis induced by cisplatin containing chemotherapy

目的 :研究国产品昂丹司琼 (欧贝 )加地塞米松防治顺铂化疗引起呕吐的疗效。方法 :5 3例恶性肿瘤患者接受顺铂为主的化疗方案 ,顺铂用法 ,2 0mg/m2 ,iv ,第 1～ 5天。昂丹司琼组 :昂丹司琼 4mg加地塞米松 5mg ,1次 /d ,第 1～ 5天 ;对照组 :甲氧氯普胺 10mg加地塞米松 5mg ,1次 /d ,第 1～ 5天。 结果 :昂丹司琼组止吐率为 82 .6 % ,明显优于甲氧氯普胺组 4 4 .5 % (P <0 .0 1)。结论 :国产品昂丹司琼价格低 ,小剂量与地塞米松联合防治顺铂引起的呕吐 ,有良好的止呕效果 。

Purpose:To evaluate the efficacy of ondansetron plus dexamethasone compared with metoclopramide plus dexamethasone against emesis induced by cisplatin (DDP) containing chemotherapy.Methods:53 malignant tumor patients received DDP containing chemotherapy. DDP was 20 mg/m 2 ,qd,from the first day to the fifth day;ondansetron was 4 mg plus dexamethasone 5 mg,qd,from the first day to the fifth day; metoclopramide was 10 mg plus dexamethasone 5mg,qd,from the first day to the fifth day. Results:The anti emetic rate of ondansetron plus dexamethasone was 82.6%,which was higher than that of metoclopramide plus dexamthasone (44.5%, P <0.01).Conclusions:The anti emetic effect of ondansetron plus dexamethasone was better than that of metoclopramide plus dexamethasone against emesis induced by DDP containing chemotherapy. It may have a future role in clinical usage.