慢阻肺急发期血清IgG及其亚类的改变

Study of derem IgG and its subclass changing in chronic obstructive pulmonary disease at acute stage

目的 :了解慢性阻塞性肺疾病 ( COPD)患者急发期 Ig G及其亚类水平。方法 :6 0例 COPD急发期患者分别用单向扩散法和速率散射比浊法检测 Ig G及其亚类水平 ,并同 5 0例健康正常者的 Ig G及其亚类比较。结果 :COPD患者急发期 Ig G3 ,Ig G4水平明显下降 ,与对照组相比差异有显著性 ( P<0 .0 1)。结论 :部分 COPD患者急发期可存在 Ig G亚类缺陷 。

Objective: It is to study the serum IgG and its subclass level of the patients with chronic obstructive pulmonary disease(COPD) at acute stage. Methods: The levels of IgG and its subclass of sixty patients with COPD at acute stage were determined with single diffusion method and turbidimetric method and compared with that of fifiy normal cases. Result: IgG 3 and IgG 4 levels of COPD patients wer significantly lower than that of normal cases. Conclusion: IgG subclass deficiencies of COPD patients probably exist and the immunomodulator should be used according to certain infection degree.