金龙利咽口服液的药理学研究

The pharmacological study of Jinlongliyan oral liquid

目的 :研究金龙利咽口服液抗菌、抗病毒、止咳化痰等药理作用。方法 :观察金龙利咽口服液对浓氨水致小鼠咳嗽及气管酚红排泌量的影响 ;了解该口服液对金黄色葡萄球菌和流感病毒的影响。结果 :该口服液低、中、高三个剂量组的镇咳和增加酚红排泌量效果均优于 3个对照组( P<0 .0 1) ;该口服液高剂量组金黄色葡萄球菌感染小鼠的死亡率显著低于 2个对照组和低、中剂量组 ( P<0 .0 1) ;中、高剂量组感染鼠的肺指数显著低于模型对照组 ( P<0 .0 5 )。结论 :金龙利咽口服液具有抗菌、抗病毒。

Objective: It is to study antibacterial, antiviral, relieving cough and reducing sputum effect of Jinlongliyan oral liquid. Methods: In order to find out the effects of Jinlongliyan oral liquid on staphylococcus aurous and influenzavirus, the cough frequency and the phenolsulfonphthalein secretory volume of windpipe were observed. Results: The cough relieving effect and phenolsulfonphthalein secretory volume of rats in windpipe of high, middle and low dose Jinlongliyan groups overbalanced that of control groups (P<0.05). The death rate of high dose group, which were infected with staphylococcus aureus, was significantly lower than that of middle and low dose groups and control groups (P<0.01). The pulmonary indexes of infected rats of middle and high dose groups were notably lower than that of control groups (P<0.01). Conclusion: Jinlongliyan oral liquid has antivirus and antibiotic function as well as relieving cough and reducing sputum function.