免疫细胞分泌研究进展

A brief introduction to the secretion mechanism in immunocytes

细胞分泌活动涉及一系列复杂的分子活动和信号转导过程 ,它是许多重要生命活动如神经递质的释放、内分泌激素分泌、蛋白质转运等的基础。故而有关细胞分泌活动的研究近年在国际上形成一个新的热点。有关免疫细胞中细胞因子的分泌机制研究的较少 ,将膜电容测量、电化学测量、光学测量、胞内信号分子光解等近年发展起来的生物物理方法引入免疫学领域 ,对研究免疫细胞的分泌调控和信号转导意义重大。

Exocytosis is a vital function of many cell types including neuron, endocrine cell and immunocyte. Secretion in immunocytes involves a complex process of signal transduction, in which many factors still remain unknown. In the last 10 years, this area has become an international hot spot of investigation, resulting in many break-through progresses. This progress was made possible by combined efforts in molecular biology, cell biology and biophysics. This review focuses on notable new knowledge and some new techniques in functional study of secretion in immunocytes.