两种药物治疗复发性生殖器疱疹的疗效观察

Clinic Observation to TWO Dugs Trea tment for Recurrent Genital Herpes

目的 比较“明竹欣”和阿昔洛韦片治疗复发性生殖器疱疹的愈后差别。方法 使用“明竹欣”和阿昔洛韦片治疗 178例复发性生殖器疱疹患者 ,疗程 10天。治疗结束后三个月及六个月各随访一次 ,记录复发情况。通过观察和询问不良反应评价其安全性。结果“明竹欣”组在三个月内的复发率为 16 .3%,半年内的复发率为 2 7.2 %;阿昔洛韦组在三个月和半年内的复发率分另为 43%和 5 8.1%。“明竹欣”组的不良反应发生率与阿昔洛韦组的不良反应发生率相近。结论“明竹欣”和阿昔洛韦用于治疗复发性的生殖器疱疹过程中 ,二者的复发率有显著性差异。“明竹欣”服药次数少 ,依从性好 ,是一种安全而且有效的药物。

Objective To compare the effectiveness of twodrugs ,Valaciclovir and Acyclovir tablet during the treatment of recurrent genital herpes.Methods One hundred and seventy-eight patients were treated by two kinds of drug,Valaciclovir and Acyclovir tablet,and finally they were followed up at the end of the third and sixth month after the treatment .The recurrence rates were also recorded.The safeties of two drugs were assessed according to the group Valaciclovir and Acyclovir were 16.3%,3.0% within three months,and were 27.2%,58.1% within six months .The rates of the bad response were almost similar between Valaciclovir and Acyclovir tablet groups.Conclusions The recurrence rates have significant difference betwenn the Valaciclovir and Acyclovir tablet groups.And the patients taking Valaciclovir have more convenient and complaisant than taking Acyclovir tablet.It was a kind of effective and safe drug.