受者细胞因子基因多态性预测肾移植术后效果的意义

Recipients' cytokine gene polymorphisms in predicting the effect of kidney transplantation

目的 探讨受者细胞因子基因多态性预测移植肾急性排斥反应的意义。方法 采用序列特异引物聚合酶链反应（PCR-SSP）方法,检测144例肾移植受者细胞因子基因型。结果TNF-α或IL-10高分泌基因型组急性排斥反应发生率高于中低分泌组,差异有极显著性意义（P<0.001）。TNF-α、IL-10高分泌基因型组急性排斥反应发生率比其它基因型组合组高,差异有显著性意义（P<0.05）。结论 受者 TNF-α和IL-10基因型是移植肾急性排斤反应的决定性因素之一。

To study the implication of recipients' cytokine genotyping in predicting a-cute rejection following kidney transplantation. Methods The cytokine genotypes of 144 consecutive cadaveric kidney allograft recipients were detected by PCR-SSP method. Results A greater proportion of the recipients with TNF-α or IL-10 high producer genotype had a higher occurrence of acute rejection than those with the TNF-α or IL-10 low producer genotype(P<0.001). The occurrence of acute rejection in the recipients with the TNF-a/IL-10 high producer genotype was higher than those with other genotypes(P< 0.05). Conclusion Recipients' TNF-a and IL-10 genotypes are determinants of acute rejection following kidney transplantation.