偏头痛患者血清神经元特异性烯醇化酶水平及其意义

A Study of Serum Neuron-Specific Enolase Level in Patients with Migraine

目的 探讨偏头痛发作期患者血清神经元特异性烯醇化酶 (S -NSE)水平及其对脑神经元的损伤。方法 采用ELISA法对偏头痛发作期 2 9例、间歇期 2 9例及正常人 33例s -NSE进行测定。结果 偏头痛发作期组s-NSE均显著高于其他两组 (P <0 0 1) ;间歇期组与对照组比较无显著差异。结论 偏头痛发作期可导致s -NSE水平升高 。

Objective To explore the level of serum neuron-specific enolase(s-NSE) and brain neuronal damage in the migraine patients during attack.Methods The level of s-NSE was assayed by ELISA in 26 patients with migraine during attack,23 patients with migraine at intervals and 20 normal controls .Results Content of s-NSE in migraine attack groups was significantly higher than that in the other two groups(P<0 01) ,and there was no statistical difference between levels of S-NSE in the interval group and normal control group.Conclusion Migraine attack could induce raise of the s-NSE level,which suggest that brain neuronal damage occurred in migraine seizures.