综合治疗对精神分裂症阴性症状的对照研究

A controlled study of the negative symptoms of schizophrenia treated by comprehensive therapy

目的 探讨心理与行为治疗合并利培酮对精神分裂症阴性症状的治疗康复作用。方法 将 6 0例以阴性症状为主的精神分裂症随机分成两组 ,进行为期 3个月的对照研究 ,分别用心理与行为治疗合并利培酮 (研究组 )和利培酮 (对照组 )治疗 ;采用BPRS、SANS、SAPS和临床疗效评定标准进行评定。结果 研究组在治疗后 2个月、3个月时BPRS、SANS两量表评分较治疗前均有非常显著性差异。而对照组仅在治疗后 3个月时两量表评分较治疗前有显著性差异。两组在治疗后 2个月、3个月时 ,BPRS、SANS减分均数与对照组比较均有非常显著性差异 (P均 <0 .0 1)。结论 心理与行为治疗合并利培酮对精神分裂症阴性症状的疗效优于单用利培酮 ,且起效快 ,应早期实施康复干预。

Objective To investigate the effect of risperidone combined with mental and behavioral therapy on the negative symptoms of Schizophrenia.Methods 60 Schizophrenic patients with mainly negative symptoms were randomly divided into study group and control group for 3 months controlled study. Study group was treated by risperidone combined with mental and behavioral therapy while control group jusy by risperidone. The clinical effects was evaluated with BPRS, SANS and SAPS. Result In study group, the score of SANS and BPRS significantly decreased at both the end of 2th month and 3th month after treatment, but in control group, the score of SANS and BPRS significantly decreased at the edn of 3th month. There were significant differences in the decreased score of SNAS and BPRS between two groups at both the end of 2th month adn 3th month (P<0.01). Conclusions Combined therapy was better than just risperidone. The patients should be gaven the rehabilitation intervention as early as possible.