认知电位P300在诊断多发脑梗塞性痴呆中的应用价值

Value of application of Auditory cognitive potential P300 in diagnosis of multiple cerebral infarction dementai

目的 :探讨多发脑梗塞性痴呆 (MCID)听觉认知电位P300变化特点及诊断价值。方法 :用简易智能状态量表 (MMSE)、临床痴呆评定量表 (CDR)和听觉P300检测MCID ,多发性脑梗塞 (MCI)和正常对照组 (NC)。结果 :MCID组与MCI和NC组比较MMSE评分明显降低 ,P300潜伏期明显延长 ,均有统计学意义 (P<0.01)。轻度痴呆者P300波幅正常 ,重者P300波幅明显降低 (P<0.05)。MCID组P300潜伏期与MMSE评分呈显著性负相关(P<0.005)。结论

Objective: To explore the change of characteristic of Auditory cognitive potential P300 in patients with multiple cerebral infarction dementia(MCID) and diagnostic significance.Methods:The mini-mental state examination(MMSE),clinical dementia review(CDR)and P300 were tested in MCID,multiple cerebral infarction(MCI)and control(NC)groups.Results:The P300 latency was significantly prolonged and MMSE score was obviously lowed in MCID group as compared with MCI and NC groups(P<0.01).The P300 amplitude was normal in light and was evident lower in serious dementia(P<0.05).There was negative correlation between P300 latency and MMSE score in MCID group(P<0.005).Conclusion:The examination of P300 is more benefit to diagnosis of MCID and observation the serious degree of disease.