复方丹参滴丸与冠心丹参滴丸抗实验性心肌缺血的药效比较研究

Comparative Research on Pharmacodynamics of Fufang Danshen Dripping Pill and Guanxin Danshen Dripping Pill in Experimental Myocardiac Ischemia

目的 :比较冠心丹参滴丸和复方丹参滴丸两种药物抗垂体后叶素 (Pit)致大鼠急性心肌缺血的药效。方法 :采用大鼠舌下静脉注射Pit造成急性心肌缺血的方法 ,观察各给药组在注射Pit后不同时间点Ⅱ导联心电图T波变化百分率 (% )、乳酸脱氢酶 (LDH )、磷酸肌酸激酶 (CPK)、超氧化物歧化酶 (SOD)、丙二醛 (MDA)含量。结果 :两种药物均能明显对抗Pit引起的急性心肌缺血的心电图变化 ;明显增加血清SOD的活性、减少MDA的含量 ;能够降低CPK的含量 ,对LDH未见明显影响。结论 :两种滴丸均具有明显对抗Pit致大鼠急性心肌缺血的作用 ,两药及不同剂量之间无明显差异 。

Objective: The pharmacodynamic effect of Fufang Danshen (Radix Salviae Miltiorrhizae) Dripping Pill and Guanxin Danshen Dripping Pill against acute myocardiac ischemia induced by pituitrin (Pit) injecting in rats was compared. Methods: The experimental model was produced by injecting Pit into sublingual vein. Five indexes were recorded at different time point after Pit injection. They were the incidence of T wave change of Ⅱ-lead of ECG (%), the content of LDH, CPK, SOD and MDA. Results: Both of the pills could markedly improve the change of AMI on ECG induced by Pit and increase the serum SOD activity, decrease MDA and CPK contents, but has no obvious influence on LDH. Conclusion: Both of the pills have the effect against acute myocardiac ischemia resulting from Pit injection. There is no obvious difference between these two pills with different doses. Their effect seems to be related with lipid peroxidation.