示波计时电位法测定环丙沙星的含量

DETERMINATION OF CIPROFLOXACIN BY OSCILLOGRAPHIC CHRONOPOTENTIOMETER

目的 测定环丙沙星 (片、胶囊、注射液 )的含量。方法 用示波计时电位法 ,于pH 6 5KCl-H3 BO3 -NaOH底液中 ,通过测量环丙沙星在示波图上所产生切口的高度 ,根据与浓度成正比的关系 ,用标准曲线法进行定量分析。结果 质量浓度在 15～ 12 0mg·L-1内 ,与切口高度呈良好线性关系 ,r =0 9998,回收率为 99 0 6 % ,RSD=2 3%。结论 示波法测定过程干扰小 。

OBJECTIVE To establish a method for determining ciprofloxacin preparations.METHODS In buffer solution pH=6.5 KCI-H 3BO 3-NaOH,a sensitivity incision due to the redox reaction of ciprofloxacin was observed on the dE/dt-E oscillogram,the incision height was linearly proportional to the drug concentration. RESULTS The linear range is 15.0～120 mg·L -1,the average recovery was 99.06% and RSD=2.3%,respectively. CONCLUSION This apparatus is simple with convenient operating and no interference was found.It can be used to control drug quality.