新近发现的一组血液恶性疾病的染色体异常

NEW ABNORMALITIES OF CHROMO SOMES IN HEMATOLOGIC MALIGNACIES

作者报告一组新近发现的血液系统恶性疾病的染色体异常。首次发现1例Burkitt淋巴瘤同时有t(8;22)和t(14;18)。这种双易位同时涉及两组癌基因c-mye和bcl-2,两组免疫球蛋白基因Ig重链和轻链基因位点。首次报告2例继发性白血病inv(4)(p15;q26),其中4p26是上皮细胞生长因子基因位点。报告了1例急性白血病12号染色体畸变。1例急性白血病多种染色体缺陷。讨论了癌基因与染色体易位的关系。

This paper reports a group of new abnormalites of chromosomes in hematologic malignacies. They are: (1) chromosomes with both translocation t(8; 22) (q24;q11) and t (14; 18,) (q32; q22) in a Burkitt's lymphoma, the break points involving two oncogenes mye and bcl-2, two Ig genes Ig heavy chain and Igλ light chain, (2) chromosome inv (4) (p15;q26) in two secondary acute nonlymphocytic leukemias (AML) involving growth factor genes; (3) chromosame 12 aberration in a AML; and (4) some chromosome deletions in a AML-M4 The relation between oncogene activation and chromosome translocation has been discussed