腹股沟斜疝的遗传研究

THE GENETIC ANALYSIS IN INGUINAL HERNIA

作者根据手术治疗的腹股沟斜疝病例的57个家系调查,发现患者135例,其中男性124例,女11例。男女比例为13.6:1。家系分析表明男性患者分离比p=0.4529,外显率为0.9058。用分离分析数学模型计算机程序分析,分离比p=0.45。外显率为0.90,与家系分析结果一致。根据两种分析结果,表明腹股沟斜疝为常染色体显性从性遗传,不完全外显,外显率为0.90～0.9058.

57 families of patients who underwent operationin our hospital because of inguinal hernia were investigated. We found 135 patients, of whom 124 were male and 11 female the sexratio being 13.6 to 1.The family analysis showed that the segregation ratio in male patients was 0.4529, and the penetrance 0.9058. On the other hand, using the computer model of segregation analysis, we obtained a segregation ratio of o 45 and a penetrance of 0.90. The resulks by family analysis and segregation analysis are consistent suggesting that inguinal hernia is an autosomal dominant sex influeuced inheritance with incomplete penetrance. The penetrance is 0.90～0.9058.