青海地区高血压病遗传度研究

STUDY OF HERITABILITY FOR HYPERTENSION AT HIGH ALTITUDE IN QINGHAI PROVINCE

根据高血压病的群体患病率与患者一、二级亲属的患病率,按Falconer估计阈值性状遗传度的公式,采取了性别分层分别计算,得出了青海高原高血压遗传度的加权平均值为59.88%±3.78%。其中53例高原世居先证者的高血压遗传度的加权平均值为56.6%±4%。为探讨高原地区遗传因素在高血压发病机制中的作用提供资料。

This article deals with the morbidity rate of hypertension by Falconer's formula. The results showed the weighted mean of heritability for hypertension at high altitude in Qinghai Province was 59.88±3.78% and that for hypertension among the native probands at high altitude 56.55±4%. The difference in morbidity of hypertension between the first and second degree relatives was statistically significant (P<0.05). The findings are important in studying the role of genetic factor in the pathogenic mechanism of hypertension at high altitude.