As_2O_3联合小剂量化疗治疗急性早幼粒细胞白血病的临床研究

Clinical Study on Effect of Combining Arsenic Trioxide with Small Dose Chemotherapy for Treatng Acute Promyelocytic Leukemia

探讨治疗急性早幼粒细胞白血病 (APL)更有效的方法 ,以延长患者的生存期 ,提高生活质量。采用As2 O3 注射液 1 0mg/d加入 1 0 %葡萄糖注射液 2 5 0～ 5 0 0mL静脉滴注 ,连续 2 8d一个疗程 ;同时用阿糖胞苷 5 0～ 1 0 0mg或高三尖杉酯碱 1～ 2mg加入 1 0 %葡萄糖注射液 2 5 0mL静脉滴注 ,7～ 1 0d为 1疗程 ,观察其临床症状、血象及骨髓象的变化 ,并追踪观察其缓解率及生存期。结果表明 ,采用As2 O3 注射液加小剂量化疗的方法治疗APL ,有明显的疗效 ,能够有效控制APL病情 ,提高完全缓解率 ,减少白血病的复发率与患者死亡率。

To find a more effective treatment for acute promyelocytic leukemia (APL) so to prolong the survival time and improve the living quality of patients with APL,22 patients with APL were divided into 2 groups 10 patients (therapy group), including initial and relapsed cases, were treated daily with 10mg arsenic trioxide in 250～500mL 10% glucose injectio for 28 days(a course) by intravenous drip and 100mg Ara C50 or 1～2mg homoharringtonine in 250ml 10% glucose injectio for 7～10 days(a course) by intravenous drip The variations in symptoms,blood routine and bone marrow were recorded,and the regimen rate and survival time were compared in the two groups It was found that the combination of arsenic trioxide with small dose chemotherapy could effectively inhibit the development of APL,raise the CR rate and reduce the recurrence and mortality of leukemia.