甲基强的松龙联合静注丙种球蛋白治疗小儿格林巴利综合征

Clinical Observation of Methyprednisolone and Intravenous Immunoglobulin in Children with Guillain - Barre Syndrome

目的:现察甲基强的松龙联合静注丙种球蛋白治疗小儿格林巴利综合征的疗效。方法:选择1999～2001年的26例格林巴利综合征患儿给予甲基强的松龙联合两种球蛋白静注作为治疗组,与1996～1998年的25例作为对照组,观察其用药后症状、体征改善情况。结果:甲基强的松龙配合丙种球蛋白静注治疗后症状、体征尤其是呼吸困难、肢体无力、饮水呛咳的开始缓解时间(约8～12h)较对照组明显提前(P<0.01),总有效率(100％)明显高于对照组(36％)(P<0.01),病死率(0％)和致残率(0％)低于对照组(8％、16％)(P<0.05),治疗组肌力、行走完全恢复正常的时间平均14、23d,对照组平均58、35d。两组对比差异显著(P<0.01)。结论:甲基强的松龙联合静注丙种球蛋白治疗小儿格林巴利综合征疗效显著,值得推广应用。

To observe the therapeutic effect of MP and IVIG on children with GBS. Method: 26 children with GBS from 1999 - 2001 were treated with MP and IVIG as therapeutic group and 25 from 1996 - 1998 were treated in routine therapeutic way as control group. Clinical symptoms and signs were observed after treatment respectively. Resuits: After treatment of MP and IVIG the overall efficacy rate was 100 % , higher than that of the control group (36 % ). The times that clinical symptoms and signs began to recover of the therapeutic group were significantly earlier compared with those of the control group, especially those of dyspnea, paralysis of extremities (8 - 12h). The mean time that the muscle powr and muscle tone turned completely normal of the therapeutic group (14、 23d) was shorter than that of the control group (58、 35d). Conclusiong: MP and IVIG had significant effect on children with GBS and would be used as a routine method to treat GBS.